8:00 am Morning Coffee

Mapping Out The Longevity Biotechnology Landscape – Part 2

8:30 am Chair’s Opening Remarks

8:40 am Addressing the Maturing Funding & Investment Landscape in Longevity

9:05 am Rejuvenation and Accelerated Aging as Therapeutic Targets

  • Ronald Kohanski Deputy Director – Division of Aging Biology, National Institute on Aging, NIH

9:30 am Challenges in Getting Us to Die Young at A Very Old Age

  • Nir Barzilai Director - Institute for Aging Research & Professor - Medicine Endocrinology & Genetics, Albert Einstein College of Medicine

9:55 am OpenCures – Better Health Together


• OpenCures is a public benefit corporation whose Mission is to minimize the time to
the development and distribution of disease interventions
• OpenCures accomplishes its Mission through the creation of a Self-Directed Research
Platform to help individuals generate, record, track, analyze health data.
• OpenCures Database (OCD) – A repository where individuals can share data,
protocols, and biospecimens to accelerate research they care about.
• OpenCures Database Collaborative (OCDC) – Those who provide resources to create
and maintain the OpenCures Database will share in the downstream value generated
by the database. We are looking to expand the Collaborative and ways to returning
value to contributors.

Innovative Therapeutic Approaches Targeting Age-Related Diseases – Part 2

10:05 am Morning Refreshments & Networking

11:05 am Cellular Senescence as a Driver of Alzheimer’s Disease (AD)

  • Julie Andersen Professor, Neurodegeneration, Buck Institute for Research on Aging

11:30 am Targeting Cellular Senescence to Develop Novel Medicines

11:55 am Targeted Systemic Senolytic Treatments For Geriatric Syndromes

12:20 pm Novel Applications of Aged Mice in Disease Research

  • Andy Schile Senior Scientific Advisor , The Jackson Laboratory

12:35 pm Lunch & Networking

1:35 pm CD24-Siglec Signaling Pathway in Regulating Host Defense to Aging & Tissue Damage Related Chronic Inflammation

  • Pan Zheng Professor, Department of Surgery, University of Maryland Baltimore

2:00 pm Linking Cellular Senescence & Osteoarthritis Development

2:25 pm Senolytic Gene Therapy in Naturally Aged Mice

2:50 pm Endogenous Retrobiome and Immunosenescence as Targets for Antiaging Therapies


• Identifying the components of the “timer” in various defined mammalian lifespans,
using the genetically determined mechanisms underlying longevity and aging.
• How sporadic activation of “retrobiome” drives spontaneous age-related
mutagenesis and interferon-mediated inflammation balanced by the immune
system that eradicates cells with activated retrobiome
• How aging may result from a misbalance of this equilibrium and, therefore, can be
prevented and treated by either pharmacological inhibition of retrobiome activity
or reversion of immunosenescence
• Development of therapies targeting a misbalance of this equilibrium,
demonstrating evidence of efficacy of our drug candidates

3:45 pm SIWA’s Humanized Monoclonal Antibody


• Harnessing the immune system to target cancer and senescent cells and other
highly glycolytic cells involved in aging and aging-related disease
• The SIWA target is produced by glycolysis
• Demonstrated targeting of senescent cells in aging-related diseases
• Demonstrated targeting of cancer cells

4:10 pm Repair Biotechnologies: Towards Reversal of Thymic Atrophy & Atherosclerosis

  • Reason Founder & CEO, Repair Biotechnologies

4:35 pm Finding the Balance; Rational Approaches to Drug Development for Longevity

5:00 pm Chair’s Closing Remarks

5:00 pm End of Longevity Therapeutics 2020

Download the Event Guide for full session details!