Examine Polycystic Kidney Disease as a First Indication for Development of the mTORC1-selective Rapamycin Analog NV-20494

Time: 2:45 pm
day: Day Two


  • Explore Kidney cyst formation and its relationship to mTORC1 dysregulation
  • Overview of prior experience in polycystic kidney disease with rapamycin and everolimus, and mechanistic considerations related to the importance of mTORC1 selectivity
  • Investigate approaches to gathering insight regarding impact of mTORC1 inhibition on endpoints of relevance to longevity